Assay Detail
Binding
CHEMBL833048
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Inhibition of [3H]-FPP incorporation into H-ras CVLS by farnesyltransferase
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.53 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361686 | — | — | 2 | 9.40 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.70 |
| CHEMBL433577 | — | — | 2 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361686 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL361686 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL433577 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL433577 | — | IC50 | = | 80.0 | nM | 7.10 |