Assay Detail
Functional
CHEMBL833073
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inhibitory activity against human CYP3A4 production
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.10 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185905 | — | — | 1 | 8.22 |
| CHEMBL186125 | — | — | 1 | 8.22 |
| CHEMBL444083 | — | — | 1 | 8.22 |
| CHEMBL187264 | — | — | 1 | 8.10 |
| CHEMBL425358 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185905 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL186125 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL444083 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL187264 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL425358 | — | IC50 | = | 18.0 | nM | 7.75 |