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Assay Detail

CHEMBL833130

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity as growth inhibition of chloroquine-resistant Plasmodium falciparum FcB1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
Ryckebusch A, Debreu-Fontaine MA, Mouray E, Grellier P, Sergheraert C, Melnyk P.
Bioorg Med Chem Lett (2005) 15 : 297 -302
PubMed 15603943 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.46 8.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3706802 1 8.19
CHEMBL153507 1 8.06
CHEMBL3706807 1 8.00
CHEMBL357948 1 7.99
CHEMBL3706805 1 7.94
CHEMBL3706808 1 7.90
CHEMBL3706806 1 7.87
CHEMBL3706804 1 7.71
CHEMBL3706801 1 7.47
CHEMBL3706809 1 6.82
CHEMBL3706803 1 6.76
CHEMBL90430 1 6.40
CHEMBL419873 1 5.86
CHEMBL3706800 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3706802 IC50 = 6.5 nM 8.19
CHEMBL153507 IC50 = 8.8 nM 8.06
CHEMBL3706807 IC50 = 9.9 nM 8.00
CHEMBL357948 IC50 = 10.2 nM 7.99
CHEMBL3706805 IC50 = 11.6 nM 7.94
CHEMBL3706808 IC50 = 12.6 nM 7.90
CHEMBL3706806 IC50 = 13.4 nM 7.87
CHEMBL3706804 IC50 = 19.6 nM 7.71
CHEMBL3706801 IC50 = 34.2 nM 7.47
CHEMBL3706809 IC50 = 152.0 nM 6.82
CHEMBL3706803 IC50 = 172.0 nM 6.76
CHEMBL90430 IC50 = 398.0 nM 6.40
CHEMBL419873 IC50 = 1380.0 nM 5.86
CHEMBL3706800 IC50 < 1000.0 nM -