Assay Detail
Functional
CHEMBL833136
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Concentration required to inhibit murine mammary carcinoma FM3A cell line proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FM3A |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.31 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.38 |
| CHEMBL190320 | — | — | 1 | 7.15 |
| CHEMBL189355 | — | — | 1 | 7.00 |
| CHEMBL371795 | — | — | 1 | 5.75 |
| CHEMBL191073 | — | — | 1 | 5.33 |
| CHEMBL362315 | — | — | 1 | 5.25 |
| CHEMBL364695 | — | — | 1 | - |
| CHEMBL364280 | — | — | 1 | - |
| CHEMBL188546 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL190320 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL189355 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL371795 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL191073 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL362315 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL364695 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364280 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188546 | — | IC50 | > | 10000.0 | nM | - |