Assay Detail
Functional
CHEMBL833177
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Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336208 | — | — | 1 | 9.00 |
| CHEMBL2093075 | — | — | 1 | 9.00 |
| CHEMBL2364572 | — | — | 2 | 8.59 |
| CHEMBL610595 | — | — | 2 | 8.35 |
| CHEMBL2093074 | — | — | 1 | 8.03 |
| CHEMBL2092819 | — | — | 1 | 7.70 |
| CHEMBL2092818 | — | — | 1 | 7.12 |
| CHEMBL611086 | — | — | 2 | 6.70 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336208 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2093075 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2364572 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL610595 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2093074 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2092819 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL610595 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2364572 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2092818 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL611086 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL611086 | — | EC50 | > | 1000.0 | nM | - |