Assay Detail
Functional
CHEMBL833181
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Inhibition of delta opioid receptor mediated GTPgammaS binding to CHO cell membranes
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.31 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361033 | — | — | 2 | 8.85 |
| CHEMBL408680 | — | — | 1 | 8.72 |
| CHEMBL361274 | — | — | 1 | 7.60 |
| CHEMBL362514 | — | — | 2 | 7.43 |
| CHEMBL188558 | — | — | 1 | 7.09 |
| CHEMBL440380 | — | — | 1 | 7.07 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 6.81 |
| CHEMBL366311 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361033 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL408680 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL361274 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL362514 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL188558 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL440380 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL361033 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL841 | LOPERAMIDE | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL362514 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL366311 | — | EC50 | = | 542.0 | nM | 6.27 |