Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL833217

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against human colon cancer SW-620 cell line
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW-620
Confidence 1 — Organism
Curated By Expert

Target

SW-620 (CHEMBL612262)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents.
Bhat BA, Dhar KL, Puri SC, Saxena AK, Shanmugavel M, Qazi GN.
Bioorg Med Chem Lett (2005) 15 : 3177 -3180
PubMed 15893928 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.25 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL191273 1 6.64
CHEMBL191306 1 5.57
CHEMBL187875 2 5.47
CHEMBL370537 1 5.30
CHEMBL190474 1 5.24
CHEMBL187461 1 5.23
CHEMBL190381 1 5.23
CHEMBL371800 1 5.17
CHEMBL189016 1 5.13
CHEMBL186882 1 5.08
CHEMBL61592 1 5.07
CHEMBL185818 1 5.06
CHEMBL372678 1 5.03
CHEMBL187451 1 5.00
CHEMBL439672 1 4.87
CHEMBL188322 1 4.79

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL191273 IC50 = 230.0 nM 6.64
CHEMBL191306 IC50 = 2670.0 nM 5.57
CHEMBL187875 IC50 = 3410.0 nM 5.47
CHEMBL370537 IC50 = 4960.0 nM 5.30
CHEMBL187875 IC50 = 5150.0 nM 5.29
CHEMBL190474 IC50 = 5800.0 nM 5.24
CHEMBL187461 IC50 = 5850.0 nM 5.23
CHEMBL190381 IC50 = 5900.0 nM 5.23
CHEMBL371800 IC50 = 6750.0 nM 5.17
CHEMBL189016 IC50 = 7350.0 nM 5.13
CHEMBL186882 IC50 = 8410.0 nM 5.08
CHEMBL61592 IC50 = 8450.0 nM 5.07
CHEMBL185818 IC50 = 8630.0 nM 5.06
CHEMBL372678 IC50 = 9250.0 nM 5.03
CHEMBL187451 IC50 = 10010.0 nM 5.00
CHEMBL439672 IC50 = 13580.0 nM 4.87
CHEMBL188322 IC50 = 16050.0 nM 4.79