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Assay Detail

CHEMBL833252

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against Plasmodium falciparum in FACS
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ.
J Med Chem (2005) 48 : 3654 -3658
PubMed 15887974 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.45 7.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 7.23
CHEMBL194878 1 5.75
CHEMBL192261 1 5.68
CHEMBL369924 1 5.67
CHEMBL374508 E-64 1 5.60
CHEMBL195844 1 5.56
CHEMBL192149 1 5.52
CHEMBL195822 1 5.30
CHEMBL191881 LEUPEPTIN 1 5.20
CHEMBL191640 1 5.10
CHEMBL191457 1 5.05
CHEMBL373022 1 5.05
CHEMBL195381 1 5.00
CHEMBL194821 1 5.00
CHEMBL370877 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 59.0 nM 7.23
CHEMBL194878 IC50 = 1760.0 nM 5.75
CHEMBL192261 IC50 = 2100.0 nM 5.68
CHEMBL369924 IC50 = 2140.0 nM 5.67
CHEMBL374508 E-64 IC50 = 2500.0 nM 5.60
CHEMBL195844 IC50 = 2740.0 nM 5.56
CHEMBL192149 IC50 = 3000.0 nM 5.52
CHEMBL195822 IC50 = 5000.0 nM 5.30
CHEMBL191881 LEUPEPTIN IC50 = 6260.0 nM 5.20
CHEMBL191640 IC50 = 8000.0 nM 5.10
CHEMBL191457 IC50 = 9000.0 nM 5.05
CHEMBL373022 IC50 = 9000.0 nM 5.05
CHEMBL195381 IC50 = 10000.0 nM 5.00
CHEMBL194821 IC50 = 10000.0 nM 5.00
CHEMBL370877 IC50 = 10000.0 nM 5.00