Assay Detail
Functional
CHEMBL833255
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Inhibitory concentration against Plasmodium falciparum FcBIR
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.71 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362894 | — | — | 1 | 6.05 |
| CHEMBL191449 | 2-(N,Ndimethylaminomethyl)ferrocenyl-methanol derivative | — | 1 | 6.00 |
| CHEMBL190212 | — | — | 1 | 6.00 |
| CHEMBL365139 | — | — | 1 | 5.96 |
| CHEMBL187788 | — | — | 1 | 5.85 |
| CHEMBL190592 | — | — | 1 | 5.82 |
| CHEMBL188101 | — | — | 1 | 5.75 |
| CHEMBL345932 | — | — | 1 | 5.66 |
| CHEMBL135287 | — | — | 1 | 5.46 |
| CHEMBL134615 | — | — | 1 | 5.40 |
| CHEMBL188093 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362894 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL191449 | 2-(N,Ndimethylaminomethyl)ferrocenyl-methanol derivative | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL190212 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL365139 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL187788 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL190592 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL188101 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL345932 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL135287 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL134615 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL188093 | — | IC50 | = | 12600.0 | nM | 4.90 |