Assay Detail
Functional
CHEMBL833264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.42 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 10.00 |
| CHEMBL434159 | — | — | 1 | 8.40 |
| CHEMBL189554 | — | — | 1 | 8.20 |
| CHEMBL363092 | — | — | 1 | 7.85 |
| CHEMBL187768 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL434159 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL189554 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL363092 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL187768 | — | EC50 | = | 22.0 | nM | 7.66 |