Assay Detail
Functional
CHEMBL833277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for reversible loss of righting reflex in Xenopus laevis tadpoles
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Tissue | Tadpole |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.76 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193243 | — | — | 1 | 5.92 |
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.72 |
| CHEMBL681 | ETOMIDATE | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193243 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL526 | PROPOFOL | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL681 | ETOMIDATE | EC50 | = | 2300.0 | nM | 5.64 |