Assay Detail
Functional
CHEMBL833280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu2 receptor
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RGT |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.14 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | 8.00 |
| CHEMBL365368 | — | — | 1 | 7.35 |
| CHEMBL192051 | — | — | 2 | 6.79 |
| CHEMBL195500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL365368 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL192051 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL192051 | — | EC50 | = | 397.0 | nM | 6.40 |
| CHEMBL195500 | — | EC50 | > | 100000.0 | nM | - |