Assay Detail

CHEMBL833350

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory activity against L1210 cell growth for 96h

ChEMBL ↗

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Target

L1210 (CHEMBL386) ↗

Open DB target context

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Primary target L1210

CHEMBL386

Anchored from Assay target.

Protein identity L1210

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	L1210
Confidence	1 — Organism
Curated By	Intermediate

Target

L1210 (CHEMBL386) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Synthesis and biological evaluation of aminopolyamines.

Bergeron RJ, Huang G, McManis JS, Yao H, Nguyen JN.
J Med Chem (2005) 48 : 3099 -3102
PubMed 15857111 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.55	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL18794	BIS(ETHYL)SPERMINE	—	1	6.70
CHEMBL364961	—	—	1	6.40
CHEMBL306840	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL18794	BIS(ETHYL)SPERMINE	IC50	=	200.0	nM	6.70
CHEMBL364961	—	IC50	=	400.0	nM	6.40
CHEMBL306840	—	IC50	>	100000.0	nM	-