Assay Detail
Functional
CHEMBL833382
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Concentration required to inhibit proliferation of HUVEC
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190984 | — | — | 1 | 6.06 |
| CHEMBL372657 | — | — | 1 | 5.97 |
| CHEMBL188386 | — | — | 1 | 5.93 |
| CHEMBL371169 | — | — | 1 | 5.86 |
| CHEMBL177688 | — | — | 1 | 5.78 |
| CHEMBL188502 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190984 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL372657 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL188386 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL371169 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL177688 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL188502 | — | IC50 | = | 1670.0 | nM | 5.78 |