Assay Detail
Functional
CHEMBL833395
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Compound was tested for the inhibition of HCV NS5B-mediated RNA synthesis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.31 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | — | 1 | 6.89 |
| CHEMBL73809 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL73809 | — | IC50 | = | 1900.0 | nM | 5.72 |