Assay Detail
Functional
CHEMBL833406
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Inhibitory concentration against Lox melanoma cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LOX IMVI |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.91 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188372 | — | — | 1 | 8.96 |
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 8.85 |
| CHEMBL181650 | — | — | 1 | 8.52 |
| CHEMBL188682 | — | — | 1 | 8.20 |
| CHEMBL186044 | — | — | 1 | 8.00 |
| CHEMBL185704 | — | — | 1 | 7.86 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.76 |
| CHEMBL189034 | — | — | 1 | 7.64 |
| CHEMBL454574 | — | — | 1 | 7.43 |
| CHEMBL425183 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188372 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL182319 | TALTOBULIN | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL181650 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL188682 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL186044 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL185704 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL189034 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL454574 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL425183 | — | IC50 | = | 1380.0 | nM | 5.86 |