Assay Detail
Functional
CHEMBL833412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency against cAMP formation in CHO cells expressing recombinant human A2B receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.89 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361925 | — | — | 1 | 6.25 |
| CHEMBL368880 | — | — | 1 | 6.17 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 6.00 |
| CHEMBL186403 | — | — | 1 | 5.92 |
| CHEMBL360837 | — | — | 1 | 5.89 |
| CHEMBL2096798 | — | — | 1 | 5.70 |
| CHEMBL360646 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361925 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL368880 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL186113 | GW-328267 | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL186403 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL360837 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2096798 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL360646 | — | EC50 | = | 4700.0 | nM | 5.33 |