Assay Detail
Functional
CHEMBL833418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for the 50% inhibition of human stomach cancer (MKN45) cell line growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189189 | — | — | 1 | 9.00 |
| CHEMBL188999 | — | — | 1 | 8.70 |
| CHEMBL363063 | — | — | 1 | 8.52 |
| CHEMBL360403 | — | — | 1 | 8.52 |
| CHEMBL364123 | — | — | 1 | 8.40 |
| CHEMBL362082 | — | — | 1 | 7.96 |
| CHEMBL363956 | — | — | 1 | 7.47 |
| CHEMBL188355 | — | — | 1 | 7.42 |
| CHEMBL186106 | — | — | 1 | 7.41 |
| CHEMBL365299 | — | — | 1 | 7.37 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.09 |
| CHEMBL183206 | — | — | 1 | 6.96 |
| CHEMBL185981 | — | — | 1 | 6.50 |
| CHEMBL186625 | — | — | 1 | 6.49 |
| CHEMBL186701 | — | — | 1 | 6.49 |
| CHEMBL184628 | — | — | 1 | 6.37 |
| CHEMBL188418 | — | — | 1 | 6.31 |
| CHEMBL364416 | — | — | 1 | 6.19 |
| CHEMBL363670 | — | — | 1 | 6.17 |
| CHEMBL363443 | — | — | 1 | 5.44 |
| CHEMBL186169 | — | — | 1 | 5.43 |
| CHEMBL363291 | — | — | 1 | 5.41 |
| CHEMBL185774 | — | — | 1 | 5.41 |
| CHEMBL185717 | — | — | 1 | 5.39 |
| CHEMBL363939 | — | — | 1 | 5.35 |
| CHEMBL187227 | — | — | 1 | 5.30 |
| CHEMBL189253 | — | — | 1 | 5.12 |
| CHEMBL187849 | — | — | 1 | - |
| CHEMBL184393 | — | — | 1 | - |
| CHEMBL189188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189189 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL188999 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL363063 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL360403 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL364123 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL362082 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL363956 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL188355 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL186106 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL365299 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL183206 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL185981 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL186625 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL186701 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL184628 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL188418 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL364416 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL363670 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL363443 | — | IC50 | = | 3615.0 | nM | 5.44 |
| CHEMBL186169 | — | IC50 | = | 3708.0 | nM | 5.43 |
| CHEMBL363291 | — | IC50 | = | 3939.0 | nM | 5.41 |
| CHEMBL185774 | — | IC50 | = | 3924.0 | nM | 5.41 |
| CHEMBL185717 | — | IC50 | = | 4074.0 | nM | 5.39 |
| CHEMBL363939 | — | IC50 | = | 4488.0 | nM | 5.35 |
| CHEMBL187227 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL189253 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL187849 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL184393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL186267 | — | IC50 | > | 10000.0 | nM | - |