Assay Detail
Functional
CHEMBL833450
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In-vitro inhibitory concentration for human tumor HCT116 cell-line was determined using MTT assay after 3 days of incubation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.63 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363863 | — | — | 1 | 9.28 |
| CHEMBL193278 | — | — | 1 | 8.85 |
| CHEMBL189205 | — | — | 1 | 8.80 |
| CHEMBL192692 | — | — | 1 | 8.77 |
| CHEMBL190617 | — | — | 1 | 8.59 |
| CHEMBL364308 | — | — | 1 | 8.59 |
| CHEMBL193123 | — | — | 1 | 8.49 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.48 |
| CHEMBL189108 | — | — | 1 | 8.42 |
| CHEMBL280320 | — | — | 1 | 8.37 |
| CHEMBL366213 | — | — | 1 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363863 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL193278 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL189205 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL192692 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL190617 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL364308 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL193123 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL189108 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL280320 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL366213 | — | IC50 | = | 4.9 | nM | 8.31 |