Assay Detail

CHEMBL833458

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory concentration in chemotaxis assay in HUVEC cells

ChEMBL ↗

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Target

HUVEC (CHEMBL613979) ↗

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Primary target HUVEC

CHEMBL613979

Anchored from Assay target.

Protein identity HUVEC

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HUVEC
Confidence	1 — Organism
Curated By	Intermediate

Target

HUVEC (CHEMBL613979) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.

Leese MP, Hejaz HA, Mahon MF, Newman SP, Purohit A, Reed MJ, Potter BV.
J Med Chem (2005) 48 : 5243 -5256
PubMed 16078843 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.44	6.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL190451	—	—	1	6.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL190451	—	IC50	=	360.0	nM	6.44