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Assay Detail

CHEMBL833489

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity of compound towards dopamine transporter determined using [3H]WIN-35 428 as radioligand
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
Carroll FI, Blough BE, Nie Z, Kuhar MJ, Howell LL, Navarro HA.
J Med Chem (2005) 48 : 2767 -2771
PubMed 15828814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 9.11 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189974 1 9.92
CHEMBL364920 1 9.70
CHEMBL364665 1 9.68
CHEMBL371812 1 9.59
CHEMBL362986 1 9.57
CHEMBL192564 1 9.39
CHEMBL191266 1 9.38
CHEMBL193308 1 9.37
CHEMBL87031 1 9.10
CHEMBL127323 1 9.09
CHEMBL195159 1 9.01
CHEMBL1790051 1 7.64
CHEMBL370805 COCAINE 4.0 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189974 IC50 = 0.12 nM 9.92
CHEMBL364920 IC50 = 0.2 nM 9.70
CHEMBL364665 IC50 = 0.21 nM 9.68
CHEMBL371812 IC50 = 0.26 nM 9.59
CHEMBL362986 IC50 = 0.27 nM 9.57
CHEMBL192564 IC50 = 0.41 nM 9.39
CHEMBL191266 IC50 = 0.42 nM 9.38
CHEMBL193308 IC50 = 0.43 nM 9.37
CHEMBL87031 IC50 = 0.79 nM 9.10
CHEMBL127323 IC50 = 0.82 nM 9.09
CHEMBL195159 IC50 = 0.98 nM 9.01
CHEMBL1790051 IC50 = 23.0 nM 7.64
CHEMBL370805 COCAINE IC50 = 89.1 nM 7.05