Assay Detail

CHEMBL833496

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Binding

Inhibition of glycogen synthase kinase-3 beta

ChEMBL ↗

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Target

Glycogen synthase kinase-3 (CHEMBL2095188) ↗

Open DB target context

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Glycogen synthase kinase-3 (CHEMBL2095188) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Glycogen synthase kinase-3

CHEMBL2095188

Anchored from Assay target.

Protein identity Glycogen synthase kinase-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	4 — Cell-line / Tissue
Curated By	Autocuration

Target

Glycogen synthase kinase-3 (CHEMBL2095188) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Mechanism of CDK5/p25 binding by CDK inhibitors.

Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A.
J Med Chem (2005) 48 : 671 -679
PubMed 15689152 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.66	7.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL126077	INDIRUBIN-3-MONOXIME	—	1	7.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL126077	INDIRUBIN-3-MONOXIME	IC50	=	22.0	nM	7.66