Assay Detail
Binding
CHEMBL833497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cyclin-dependent kinase 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.09 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300389 | — | — | 1 | 7.77 |
| CHEMBL177434 | — | — | 1 | 6.30 |
| CHEMBL178484 | — | — | 1 | 5.65 |
| CHEMBL355578 | — | — | 1 | 5.62 |
| CHEMBL368786 | — | — | 1 | 5.09 |
| CHEMBL177688 | — | — | 1 | - |
| CHEMBL368997 | — | — | 1 | - |
| CHEMBL177548 | — | — | 1 | - |
| CHEMBL369217 | — | — | 1 | - |
| CHEMBL178743 | — | — | 1 | - |
| CHEMBL177384 | — | — | 1 | - |
| CHEMBL177806 | — | — | 1 | - |
| CHEMBL368936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300389 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL177434 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL178484 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL355578 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL368786 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL177688 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL368997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL177548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL369217 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL178743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL177384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL177806 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL368936 | — | IC50 | > | 10000.0 | nM | - |