Assay Detail
Functional
CHEMBL833509
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Inhibitory concentration was measured by the incorporation of [14C]-thymidine in (human breast carcinoma) MDA-MB-435 cell line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.53 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190281 | — | — | 1 | 7.70 |
| CHEMBL193177 | — | — | 1 | 7.16 |
| CHEMBL192308 | — | — | 1 | 7.05 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.80 |
| CHEMBL366211 | — | — | 1 | 6.72 |
| CHEMBL415773 | — | — | 1 | 6.70 |
| CHEMBL189099 | — | — | 1 | 6.54 |
| CHEMBL190627 | — | — | 1 | 6.49 |
| CHEMBL189011 | — | — | 1 | 6.48 |
| CHEMBL193184 | — | — | 1 | 6.47 |
| CHEMBL192827 | — | — | 1 | 6.25 |
| CHEMBL371198 | — | — | 1 | 6.00 |
| CHEMBL190061 | — | — | 1 | 5.97 |
| CHEMBL363589 | — | — | 1 | 5.96 |
| CHEMBL189543 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190281 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL193177 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL192308 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL366211 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL415773 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL189099 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL190627 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL189011 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL193184 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL192827 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL371198 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL190061 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL363589 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL189543 | — | IC50 | = | 2150.0 | nM | 5.67 |