Assay Detail
Functional
CHEMBL833510
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Inhibitory concentration was measured by the incorporation of [14C]thymidine in (human breast carcinoma) MDA-MB-468 cell line
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190281 | — | — | 1 | 6.22 |
| CHEMBL192308 | — | — | 1 | - |
| CHEMBL190096 | — | — | 1 | - |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190281 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL192308 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL190096 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL189963 | PALBOCICLIB | IC50 | > | 3000.0 | nM | - |