Assay Detail
Binding
CHEMBL833531
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Inhibitory activity against DNA-dependent protein kinase (DNA-PK) at 0.5 uM
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
DNA-dependent protein kinase catalytic subunit (CHEMBL3142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.49 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188678 | — | — | 1 | 7.70 |
| CHEMBL186048 | — | — | 1 | 7.40 |
| CHEMBL435507 | — | — | 1 | 6.72 |
| CHEMBL360183 | — | — | 1 | 6.52 |
| CHEMBL189552 | — | — | 1 | 6.22 |
| CHEMBL362729 | — | — | 1 | 6.16 |
| CHEMBL187562 | — | — | 1 | 6.10 |
| CHEMBL362521 | — | — | 1 | 6.10 |
| CHEMBL363755 | — | — | 1 | 6.05 |
| CHEMBL367315 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188678 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL186048 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL435507 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL360183 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL189552 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL362729 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL187562 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL362521 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL363755 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL367315 | — | IC50 | = | 1300.0 | nM | 5.89 |