Assay Detail
Binding
CHEMBL833534
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Inhibitory concentration against falcipain-2 of Plasmodium falciparum W2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.80 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182790 | — | — | 1 | 6.43 |
| CHEMBL181752 | — | — | 1 | 6.33 |
| CHEMBL181504 | — | — | 1 | 6.21 |
| CHEMBL183396 | — | — | 1 | 6.19 |
| CHEMBL182795 | — | — | 1 | 5.75 |
| CHEMBL183005 | — | — | 1 | 5.58 |
| CHEMBL183767 | — | — | 1 | 5.08 |
| CHEMBL181902 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182790 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL181752 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL181504 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL183396 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL182795 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL183005 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL183767 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL181902 | — | IC50 | = | 14000.0 | nM | 4.85 |