Assay Detail
Binding
CHEMBL833549
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Inhibitory concentration against Matrix metalloprotease-13 at 1 uM
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.21 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369302 | — | — | 1 | 8.40 |
| CHEMBL359502 | — | — | 1 | 8.30 |
| CHEMBL183132 | — | — | 1 | 8.15 |
| CHEMBL181328 | — | — | 1 | 8.10 |
| CHEMBL361959 | — | — | 1 | 8.05 |
| CHEMBL180181 | — | — | 1 | 7.96 |
| CHEMBL181208 | — | — | 1 | 7.77 |
| CHEMBL178732 | — | — | 1 | 7.70 |
| CHEMBL180130 | — | — | 1 | 7.68 |
| CHEMBL178929 | — | — | 1 | 7.51 |
| CHEMBL360257 | — | — | 1 | 7.50 |
| CHEMBL362797 | — | — | 1 | 7.44 |
| CHEMBL180333 | — | — | 1 | 7.28 |
| CHEMBL180484 | — | — | 1 | 7.19 |
| CHEMBL180197 | — | — | 1 | 7.06 |
| CHEMBL181317 | — | — | 1 | 6.89 |
| CHEMBL181365 | — | — | 1 | 6.85 |
| CHEMBL361809 | — | — | 1 | 6.85 |
| CHEMBL181094 | — | — | 1 | 6.75 |
| CHEMBL359920 | — | — | 1 | 6.65 |
| CHEMBL180891 | — | — | 1 | 6.52 |
| CHEMBL180047 | — | — | 1 | 6.51 |
| CHEMBL180627 | — | — | 1 | 6.51 |
| CHEMBL180245 | — | — | 1 | 6.44 |
| CHEMBL181110 | — | — | 1 | 6.40 |
| CHEMBL369574 | — | — | 1 | 6.35 |
| CHEMBL180410 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369302 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL359502 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL183132 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL181328 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL361959 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL180181 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL181208 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL178732 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL180130 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL178929 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL360257 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL362797 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL180333 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL180484 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL180197 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL181317 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL181365 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL361809 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL181094 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL359920 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL180891 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL180047 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL180627 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL180245 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL181110 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL369574 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL180410 | — | IC50 | = | 1063.0 | nM | 5.97 |