Assay Detail
Binding
CHEMBL833559
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Inhibitory effect on human platelet 12-lipoxygenase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.27 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186752 | — | — | 1 | 6.40 |
| CHEMBL150098 | — | — | 1 | 6.39 |
| CHEMBL362761 | — | — | 1 | 6.16 |
| CHEMBL360190 | BASTADIN 7 | — | 1 | 5.64 |
| CHEMBL185893 | — | — | 1 | 5.29 |
| CHEMBL186098 | — | — | 1 | 5.22 |
| CHEMBL148503 | — | — | 1 | 5.21 |
| CHEMBL184398 | — | — | 1 | 5.16 |
| CHEMBL184450 | — | — | 1 | 5.00 |
| CHEMBL186099 | — | — | 1 | 4.92 |
| CHEMBL185753 | SPONGIADIOXIN C | — | 1 | 4.52 |
| CHEMBL187472 | — | — | 1 | 4.33 |
| CHEMBL185828 | SPONGIADIOXIN A | — | 1 | 4.30 |
| CHEMBL186007 | — | — | 1 | - |
| CHEMBL111507 | — | — | 1 | - |
| CHEMBL186858 | — | — | 1 | - |
| CHEMBL187292 | — | — | 1 | - |
| CHEMBL184410 | — | — | 1 | - |
| CHEMBL57284 | — | — | 1 | - |
| CHEMBL185651 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186752 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL150098 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL362761 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL360190 | BASTADIN 7 | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL185893 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL186098 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL148503 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL184398 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL184450 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL186099 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL185753 | SPONGIADIOXIN C | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL187472 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL185828 | SPONGIADIOXIN A | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL186007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL186858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL187292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL184410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57284 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185651 | — | IC50 | > | 100000.0 | nM | - |