Assay Detail
Binding
CHEMBL833584
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Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.27 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182407 | — | — | 1 | 8.52 |
| CHEMBL183703 | — | — | 1 | 8.40 |
| CHEMBL181495 | — | — | 1 | 8.30 |
| CHEMBL181334 | — | — | 1 | 8.30 |
| CHEMBL182749 | — | — | 1 | 8.22 |
| CHEMBL368427 | — | — | 1 | 8.07 |
| CHEMBL361233 | — | — | 1 | 8.05 |
| CHEMBL361841 | — | — | 1 | 7.92 |
| CHEMBL182173 | — | — | 1 | 7.85 |
| CHEMBL181756 | — | — | 1 | 7.85 |
| CHEMBL182358 | — | — | 1 | 7.82 |
| CHEMBL360337 | — | — | 1 | 7.82 |
| CHEMBL181434 | — | — | 1 | 7.82 |
| CHEMBL361548 | — | — | 1 | 7.70 |
| CHEMBL369306 | — | — | 1 | 7.62 |
| CHEMBL360691 | — | — | 1 | 7.60 |
| CHEMBL360077 | — | — | 1 | 7.60 |
| CHEMBL425346 | — | — | 1 | 7.58 |
| CHEMBL363706 | — | — | 1 | 7.47 |
| CHEMBL185509 | — | — | 1 | 7.30 |
| CHEMBL182282 | — | — | 1 | 7.22 |
| CHEMBL180452 | — | — | 1 | 7.09 |
| CHEMBL425883 | — | — | 1 | 6.96 |
| CHEMBL183341 | — | — | 1 | 6.92 |
| CHEMBL183187 | — | — | 1 | 6.57 |
| CHEMBL181358 | — | — | 1 | 6.52 |
| CHEMBL361171 | — | — | 1 | 6.25 |
| CHEMBL182722 | — | — | 1 | 5.89 |
| CHEMBL173050 | — | — | 1 | 5.82 |
| CHEMBL433565 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182407 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL183703 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL181495 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL181334 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182749 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL368427 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL361233 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL361841 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL182173 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL181756 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL182358 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL360337 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL181434 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL361548 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL369306 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL360077 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL360691 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL425346 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL363706 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL185509 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL182282 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL180452 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL425883 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL183341 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL183187 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL181358 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL361171 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL182722 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL173050 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL433565 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL182417 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL183024 | — | IC50 | = | 20000.0 | nM | 4.70 |