Assay Detail
Binding
CHEMBL833585
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Inhibitory activity against rat liver microsomal Acyl coenzyme A:cholesterol acyltransferase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.24 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | — | 1 | 7.70 |
| CHEMBL179229 | PYRIPYROPENE A | — | 1 | 6.77 |
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | - |
| CHEMBL15927 | OLEAMIDE | — | 1 | - |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | - |
| CHEMBL64122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL179229 | PYRIPYROPENE A | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL8659 | OLEIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL15927 | OLEAMIDE | IC50 | = | 170000.0 | nM | - |
| CHEMBL267476 | LINOLEIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL64122 | — | IC50 | = | 150000.0 | nM | - |