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Assay Detail

CHEMBL833649

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Functional
Ability to compete with [3H]SPD for the polyamine transport apparatus in L1210 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Intermediate

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Polyamine-vectored iron chelators: the role of charge.
Bergeron RJ, Bharti N, Wiegand J, McManis JS, Yao H, Prokai L.
J Med Chem (2005) 48 : 4120 -4137
PubMed 15943485 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 5.12 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL18794 BIS(ETHYL)SPERMINE 1 5.80
CHEMBL191563 1 5.51
CHEMBL150911 1 5.43
CHEMBL192275 1 5.24
CHEMBL191237 1 4.57
CHEMBL427003 1 4.14
CHEMBL306840 1 -
CHEMBL194002 1 -
CHEMBL70927 DEFERIPRONE 4.0 1 -
CHEMBL432481 DEFERITRIN 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL18794 BIS(ETHYL)SPERMINE Ki = 1600.0 nM 5.80
CHEMBL191563 Ki = 3100.0 nM 5.51
CHEMBL150911 Ki = 3700.0 nM 5.43
CHEMBL192275 Ki = 5700.0 nM 5.24
CHEMBL191237 Ki = 27000.0 nM 4.57
CHEMBL427003 Ki = 73000.0 nM 4.14
CHEMBL306840 Ki = 285000.0 nM -
CHEMBL194002 Ki > 500000.0 nM -
CHEMBL70927 DEFERIPRONE Ki > 500000.0 nM -
CHEMBL432481 DEFERITRIN Ki > 500000.0 nM -