Assay Detail
Functional
CHEMBL833650
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Binding affinity for alpha-2A-adrenergic receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.75 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91157 | — | — | 1 | 9.10 |
| CHEMBL419316 | — | — | 1 | 8.85 |
| CHEMBL92860 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91157 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL419316 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL92860 | — | Ki | = | 5.0 | nM | 8.30 |