Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL833656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory constant against stimulation of alkaline phosphatase activity in Ishikawa cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Ishikawa
Confidence 1 — Organism
Curated By Intermediate

Target

Ishikawa (CHEMBL614649)
Type CELL-LINE
Organism Homo sapiens

Publication

Nonpolar and short side chain groups at C-11beta of estradiol result in antiestrogens.
Zhang JX, Labaree DC, Hochberg RB.
J Med Chem (2005) 48 : 1428 -1447
PubMed 15743187 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 8.92 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1627715 1 10.05
CHEMBL1628013 1 10.00
CHEMBL1628006 1 9.70
CHEMBL1627711 1 9.52
CHEMBL1627723 1 9.52
CHEMBL1627718 1 9.52
CHEMBL1627719 1 9.52
CHEMBL1627717 1 9.52
CHEMBL1627720 1 9.40
CHEMBL1628014 1 9.00
CHEMBL1627721 1 8.96
CHEMBL1627998 1 8.68
CHEMBL1627760 1 8.57
CHEMBL1627999 1 8.51
CHEMBL1627754 1 8.28
CHEMBL2068756 1 7.89
CHEMBL1627725 1 7.80
CHEMBL1627724 1 7.70
CHEMBL1627712 1 7.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1627715 Ki = 0.09 nM 10.05
CHEMBL1628013 Ki = 0.1 nM 10.00
CHEMBL1628006 Ki = 0.2 nM 9.70
CHEMBL1627711 Ki = 0.3 nM 9.52
CHEMBL1627723 Ki = 0.3 nM 9.52
CHEMBL1627718 Ki = 0.3 nM 9.52
CHEMBL1627719 Ki = 0.3 nM 9.52
CHEMBL1627717 Ki = 0.3 nM 9.52
CHEMBL1627720 Ki = 0.4 nM 9.40
CHEMBL1628014 Ki = 1.0 nM 9.00
CHEMBL1627721 Ki = 1.1 nM 8.96
CHEMBL1627998 Ki = 2.1 nM 8.68
CHEMBL1627760 Ki = 2.7 nM 8.57
CHEMBL1627999 Ki = 3.1 nM 8.51
CHEMBL1627754 Ki = 5.2 nM 8.28
CHEMBL2068756 Ki = 13.0 nM 7.89
CHEMBL1627725 Ki = 16.0 nM 7.80
CHEMBL1627724 Ki = 20.0 nM 7.70
CHEMBL1627712 Ki = 55.0 nM 7.26