Assay Detail
Functional
CHEMBL833783
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Cytotoxicity against doxorubicin resistant LoVo cell line was determined against 144 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design, synthesis, and biological evaluation of bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.09 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185043 | — | — | 1 | 8.51 |
| CHEMBL188103 | — | — | 1 | 8.12 |
| CHEMBL187738 | — | — | 1 | 7.23 |
| CHEMBL186004 | — | — | 1 | 7.17 |
| CHEMBL189214 | — | — | 1 | 6.54 |
| CHEMBL362087 | — | — | 1 | 6.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185043 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL188103 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL187738 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL186004 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL189214 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL362087 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2300.0 | nM | 5.64 |