Assay Detail
Functional
CHEMBL833796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit cell proliferation by 50% in KB3-1 tumor cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.72 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184515 | — | — | 1 | 9.00 |
| CHEMBL186397 | — | — | 1 | 8.70 |
| CHEMBL184236 | — | — | 1 | 7.52 |
| CHEMBL187041 | — | — | 1 | 7.40 |
| CHEMBL187426 | — | — | 1 | 7.40 |
| CHEMBL186690 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184515 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL186397 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL184236 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187041 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL187426 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL186690 | — | IC50 | = | 500.0 | nM | 6.30 |