Assay Detail
Functional
CHEMBL833801
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Cytotoxicity against MAC15A mouse adenocarcinomas of the colon cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MAC15A |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.56 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366168 | — | — | 1 | 5.99 |
| CHEMBL1162901 | — | — | 1 | 5.95 |
| CHEMBL450632 | — | — | 1 | 5.94 |
| CHEMBL189923 | — | — | 1 | 5.87 |
| CHEMBL371382 | — | — | 1 | 5.76 |
| CHEMBL191791 | — | — | 1 | 5.76 |
| CHEMBL193834 | — | — | 1 | 5.72 |
| CHEMBL365520 | — | — | 1 | 5.65 |
| CHEMBL370710 | — | — | 1 | 5.48 |
| CHEMBL363821 | — | — | 1 | 5.46 |
| CHEMBL189152 | — | — | 1 | 5.45 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.40 |
| CHEMBL373109 | — | — | 1 | 5.39 |
| CHEMBL191734 | — | — | 1 | 5.37 |
| CHEMBL92023 | — | — | 1 | 5.32 |
| CHEMBL191789 | — | — | 1 | 5.28 |
| CHEMBL192343 | — | — | 1 | 5.22 |
| CHEMBL190189 | — | — | 1 | 5.09 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366168 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1162901 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL450632 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL189923 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL371382 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL191791 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL193834 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL365520 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL370710 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL363821 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL189152 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL373109 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL191734 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL92023 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL191789 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL192343 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL190189 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | - | nM | - |