Assay Detail
Functional
CHEMBL833806
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inhibition of TNF-alpha-induced ICAM-1 expression in the human microvascular endothelial cell line HMEC-1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of ether analogues derived from HUN-7293 and evaluation as inhibitors of VCAM-1 expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.32 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448561 | — | — | 1 | 7.60 |
| CHEMBL186986 | — | — | 1 | 6.75 |
| CHEMBL363016 | — | — | 1 | 5.78 |
| CHEMBL364599 | — | — | 1 | 5.16 |
| CHEMBL360865 | — | — | 1 | - |
| CHEMBL184339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448561 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL186986 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL363016 | — | IC50 | = | 1662.0 | nM | 5.78 |
| CHEMBL364599 | — | IC50 | = | 6925.0 | nM | 5.16 |
| CHEMBL360865 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL184339 | — | IC50 | > | 30000.0 | nM | - |