Assay Detail
Functional
CHEMBL833809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for the 50% inhibition of human lung caner (A549) cell line growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.46 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363063 | — | — | 1 | 8.22 |
| CHEMBL364123 | — | — | 1 | 7.64 |
| CHEMBL189189 | — | — | 1 | 7.64 |
| CHEMBL188999 | — | — | 1 | 7.58 |
| CHEMBL188355 | — | — | 1 | 7.28 |
| CHEMBL186106 | — | — | 1 | 7.21 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.93 |
| CHEMBL360403 | — | — | 1 | 6.92 |
| CHEMBL362082 | — | — | 1 | 6.64 |
| CHEMBL183206 | — | — | 1 | 6.22 |
| CHEMBL186701 | — | — | 1 | 6.21 |
| CHEMBL363956 | — | — | 1 | 6.17 |
| CHEMBL186625 | — | — | 1 | 6.14 |
| CHEMBL365299 | — | — | 1 | 6.09 |
| CHEMBL185981 | — | — | 1 | 5.35 |
| CHEMBL188418 | — | — | 1 | 5.19 |
| CHEMBL184628 | — | — | 1 | 5.12 |
| CHEMBL363291 | — | — | 1 | 5.07 |
| CHEMBL364416 | — | — | 1 | 5.04 |
| CHEMBL363670 | — | — | 1 | - |
| CHEMBL189253 | — | — | 1 | - |
| CHEMBL186267 | — | — | 1 | - |
| CHEMBL363322 | — | — | 1 | - |
| CHEMBL185982 | — | — | 1 | - |
| CHEMBL186169 | — | — | 1 | - |
| CHEMBL363939 | — | — | 1 | - |
| CHEMBL184393 | — | — | 1 | - |
| CHEMBL187227 | — | — | 1 | - |
| CHEMBL187849 | — | — | 1 | - |
| CHEMBL185717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363063 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL364123 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL189189 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL188999 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL188355 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL186106 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL360403 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL362082 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL183206 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL186701 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL363956 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL186625 | — | IC50 | = | 729.0 | nM | 6.14 |
| CHEMBL365299 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL185981 | — | IC50 | = | 4486.0 | nM | 5.35 |
| CHEMBL188418 | — | IC50 | = | 6499.0 | nM | 5.19 |
| CHEMBL184628 | — | IC50 | = | 7533.0 | nM | 5.12 |
| CHEMBL363291 | — | IC50 | = | 8562.0 | nM | 5.07 |
| CHEMBL364416 | — | IC50 | = | 9212.0 | nM | 5.04 |
| CHEMBL363670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL186267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL186169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL184393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187227 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL187849 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL363443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185774 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189188 | — | IC50 | > | 10000.0 | nM | - |