Assay Detail
Functional
CHEMBL833844
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Effective concentration for Plasmodium falciparum W2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.86 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144037 | — | — | 1 | 7.64 |
| CHEMBL182196 | — | — | 1 | 7.30 |
| CHEMBL148021 | — | — | 1 | 7.21 |
| CHEMBL178208 | — | — | 1 | 7.15 |
| CHEMBL178821 | — | — | 1 | 6.99 |
| CHEMBL181177 | — | — | 1 | 6.90 |
| CHEMBL180671 | — | — | 1 | 6.57 |
| CHEMBL178200 | — | — | 1 | 6.57 |
| CHEMBL180709 | — | — | 1 | 6.54 |
| CHEMBL359757 | — | — | 1 | 6.54 |
| CHEMBL144539 | — | — | 1 | 6.51 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144037 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL182196 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL148021 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL178208 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL178821 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL181177 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL180671 | — | EC50 | = | 267.0 | nM | 6.57 |
| CHEMBL178200 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL180709 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL359757 | — | EC50 | = | 287.0 | nM | 6.54 |
| CHEMBL144539 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 382.0 | nM | 6.42 |