Assay Detail
Functional
CHEMBL833860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) (CHEMBL2111351) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.05 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34704 | — | — | 1 | 6.54 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.48 |
| CHEMBL180308 | — | — | 1 | 5.05 |
| CHEMBL365404 | — | — | 1 | 4.98 |
| CHEMBL184940 | — | — | 1 | 4.95 |
| CHEMBL361195 | — | — | 1 | 4.91 |
| CHEMBL182656 | — | — | 1 | 4.85 |
| CHEMBL359722 | — | — | 1 | 4.79 |
| CHEMBL181589 | — | — | 1 | 4.71 |
| CHEMBL185291 | — | — | 1 | 4.69 |
| CHEMBL182807 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34704 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL180308 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL365404 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL184940 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL361195 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL182656 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL359722 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL181589 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL185291 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL182807 | — | IC50 | = | 25300.0 | nM | 4.60 |