Assay Detail
Functional
CHEMBL833865
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Inhibition of human SW620 cell proliferation
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 6.00 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427315 | — | — | 1 | 6.85 |
| CHEMBL360662 | — | — | 1 | 6.85 |
| CHEMBL179313 | — | — | 1 | 6.71 |
| CHEMBL179274 | — | — | 1 | 6.54 |
| CHEMBL360754 | — | — | 1 | 6.52 |
| CHEMBL426051 | — | — | 1 | 6.51 |
| CHEMBL360211 | — | — | 1 | 6.51 |
| CHEMBL178312 | — | — | 1 | 6.51 |
| CHEMBL360979 | — | — | 1 | 6.48 |
| CHEMBL179659 | — | — | 1 | 6.45 |
| CHEMBL176199 | — | — | 1 | 6.44 |
| CHEMBL175492 | — | — | 1 | 6.44 |
| CHEMBL360958 | — | — | 1 | 6.40 |
| CHEMBL179607 | — | — | 1 | 6.40 |
| CHEMBL175726 | — | — | 1 | 6.39 |
| CHEMBL179052 | — | — | 1 | 6.34 |
| CHEMBL434720 | — | — | 1 | 6.31 |
| CHEMBL178199 | — | — | 1 | 6.30 |
| CHEMBL178654 | HKI-357 | 1.0 | 1 | 6.29 |
| CHEMBL440935 | — | — | 1 | 6.27 |
| CHEMBL179123 | — | — | 1 | 6.26 |
| CHEMBL360028 | — | — | 1 | 6.26 |
| CHEMBL362232 | — | — | 1 | 6.24 |
| CHEMBL179577 | — | — | 1 | 6.24 |
| CHEMBL180516 | — | — | 1 | 6.23 |
| CHEMBL180415 | — | — | 1 | 6.23 |
| CHEMBL179521 | — | — | 1 | 6.21 |
| CHEMBL361343 | — | — | 1 | 6.19 |
| CHEMBL153763 | — | — | 1 | 6.18 |
| CHEMBL180018 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427315 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL360662 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL179313 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL179274 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL360754 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL426051 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL360211 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL178312 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL360979 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL179659 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL176199 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL175492 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL179607 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL360958 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL175726 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL179052 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL434720 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL178199 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL178654 | HKI-357 | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL440935 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL179123 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL360028 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL362232 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL179577 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL180415 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL180516 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL179521 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL361343 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL153763 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL180018 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL607707 | PELITINIB | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL180022 | NERATINIB | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL179652 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL178573 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL362611 | — | IC50 | = | 792.0 | nM | 6.10 |
| CHEMBL178958 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL178144 | — | IC50 | = | 817.0 | nM | 6.09 |
| CHEMBL367492 | — | IC50 | = | 842.0 | nM | 6.08 |
| CHEMBL180227 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL179766 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL369299 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL368702 | — | IC50 | = | 951.0 | nM | 6.02 |
| CHEMBL360519 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL175558 | — | IC50 | = | 961.0 | nM | 6.02 |
| CHEMBL179363 | — | IC50 | = | 965.0 | nM | 6.01 |
| CHEMBL359629 | — | IC50 | = | 973.0 | nM | 6.01 |
| CHEMBL175840 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL424959 | — | IC50 | = | 1019.0 | nM | 5.99 |
| CHEMBL179164 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL180175 | — | IC50 | = | 1093.0 | nM | 5.96 |