Assay Detail
Functional
CHEMBL833900
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Inhibition of MCF-7 cell proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.66 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328190 | LASOFOXIFENE | 4.0 | 1 | 10.00 |
| CHEMBL183162 | — | — | 1 | 9.82 |
| CHEMBL183333 | — | — | 1 | 9.60 |
| CHEMBL304552 | — | — | 1 | 8.52 |
| CHEMBL179929 | — | — | 1 | 7.24 |
| CHEMBL180085 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328190 | LASOFOXIFENE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL183162 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL183333 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL304552 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL179929 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL180085 | — | IC50 | = | 164.0 | nM | 6.79 |