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Assay Detail

CHEMBL833904

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Functional
Compound tested on intracellular parasites Toxoplasma gondii in vero cells after 24 h
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

Toxoplasma gondii (CHEMBL612888)
Type ORGANISM
Organism Toxoplasma gondii

Publication

Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity.
Tenório RP, Carvalho CS, Pessanha CS, de Lima JG, de Faria AR, Alves AJ, de Melo EJ, Góes AJ.
Bioorg Med Chem Lett (2005) 15 : 2575 -2578
PubMed 15863319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.04 4.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445654 1 4.10
CHEMBL194029 1 4.10
CHEMBL467 HYDROXYUREA 4.0 1 4.00
CHEMBL439 SULFADIAZINE 4.0 1 4.00
CHEMBL193474 1 4.00
CHEMBL195506 1 -
CHEMBL365175 1 -
CHEMBL193649 1 -
CHEMBL194091 1 -
CHEMBL370876 1 -
CHEMBL194123 1 -
CHEMBL370691 1 -
CHEMBL193804 1 -
CHEMBL191686 1 -
CHEMBL195486 1 -
CHEMBL195459 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445654 IC50 = 80000.0 nM 4.10
CHEMBL194029 IC50 = 80000.0 nM 4.10
CHEMBL467 HYDROXYUREA IC50 = 100000.0 nM 4.00
CHEMBL439 SULFADIAZINE IC50 = 100000.0 nM 4.00
CHEMBL193474 IC50 = 100000.0 nM 4.00
CHEMBL195506 IC50 = 500000.0 nM -
CHEMBL365175 IC50 = 500000.0 nM -
CHEMBL193649 IC50 = 500000.0 nM -
CHEMBL194091 IC50 = 500000.0 nM -
CHEMBL370876 IC50 = 500000.0 nM -
CHEMBL194123 IC50 = 500000.0 nM -
CHEMBL370691 IC50 = 500000.0 nM -
CHEMBL193804 IC50 = 500000.0 nM -
CHEMBL191686 IC50 = 500000.0 nM -
CHEMBL195486 IC50 = 500000.0 nM -
CHEMBL195459 IC50 = 3000000.0 nM -