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Assay Detail

CHEMBL833941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for inhibition of tubulin polymerisation
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Beta tubulin (CHEMBL3186)
Type SINGLE PROTEIN
Organism Leishmania donovani

Publication

Novel diarylsulfonylurea derivatives as potent antimitotic agents.
Kim S, Park JH, Koo SY, Kim JI, Kim MH, Kim JE, Jo K, Choi HG, Lee SB, Jung SH.
Bioorg Med Chem Lett (2004) 14 : 6075 -6078
PubMed 15546733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.14 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL186524 1 5.82
CHEMBL188768 1 5.82
CHEMBL188453 1 5.80
CHEMBL191213 1 5.70
CHEMBL361893 1 5.46
CHEMBL190702 1 5.40
CHEMBL362529 1 5.26
CHEMBL187414 1 5.22
CHEMBL361244 1 4.99
CHEMBL362333 1 4.98
CHEMBL365509 1 4.66
CHEMBL187716 1 4.60
CHEMBL363690 1 4.52
CHEMBL364096 1 4.52
CHEMBL188420 1 4.40
CHEMBL362352 1 -
CHEMBL90555 VINCRISTINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL186524 IC50 = 1500.0 nM 5.82
CHEMBL188768 IC50 = 1500.0 nM 5.82
CHEMBL188453 IC50 = 1600.0 nM 5.80
CHEMBL191213 IC50 = 2000.0 nM 5.70
CHEMBL361893 IC50 = 3500.0 nM 5.46
CHEMBL190702 IC50 = 4000.0 nM 5.40
CHEMBL362529 IC50 = 5500.0 nM 5.26
CHEMBL187414 IC50 = 6000.0 nM 5.22
CHEMBL361244 IC50 = 10300.0 nM 4.99
CHEMBL362333 IC50 = 10500.0 nM 4.98
CHEMBL365509 IC50 = 22000.0 nM 4.66
CHEMBL187716 IC50 = 25000.0 nM 4.60
CHEMBL363690 IC50 = 30000.0 nM 4.52
CHEMBL364096 IC50 = 30000.0 nM 4.52
CHEMBL188420 IC50 = 40000.0 nM 4.40
CHEMBL362352 IC50 < 1000.0 nM -
CHEMBL90555 VINCRISTINE IC50 < 1000.0 nM -