Assay Detail
Functional
CHEMBL833987
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Inhibitory concentration against MCF-7 human breast carcinoma cell line
20
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.37 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178282 | — | — | 3 | 7.72 |
| CHEMBL180073 | — | — | 3 | 7.70 |
| CHEMBL179259 | — | — | 1 | 7.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL179731 | — | — | 1 | 7.64 |
| CHEMBL179686 | — | — | 1 | 7.60 |
| CHEMBL178855 | — | — | 1 | 7.58 |
| CHEMBL362024 | — | — | 1 | 7.50 |
| CHEMBL179293 | — | — | 1 | 7.46 |
| CHEMBL262923 | — | — | 1 | 7.40 |
| CHEMBL180374 | — | — | 1 | 7.16 |
| CHEMBL178461 | — | — | 1 | 6.98 |
| CHEMBL178551 | — | — | 1 | 6.94 |
| CHEMBL178912 | — | — | 1 | 6.75 |
| CHEMBL180375 | — | — | 1 | 6.75 |
| CHEMBL368646 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178282 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL178282 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL180073 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL179259 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL180073 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL179731 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL179686 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL178855 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL178282 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL180073 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL362024 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL179293 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL262923 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL180374 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL178461 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL178551 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL180375 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL178912 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL368646 | — | IC50 | = | 331.0 | nM | 6.48 |