Assay Detail
Functional
CHEMBL833997
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Inhibition of prostate cancer (PC-3) cell proliferation
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.67 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186731 | — | — | 1 | 5.60 |
| CHEMBL264504 | — | — | 1 | 5.48 |
| CHEMBL362773 | — | — | 1 | 5.48 |
| CHEMBL364175 | — | — | 1 | 5.47 |
| CHEMBL362530 | — | — | 1 | 5.47 |
| CHEMBL186760 | — | — | 1 | 5.46 |
| CHEMBL188890 | — | — | 1 | 5.39 |
| CHEMBL185959 | — | — | 1 | 5.38 |
| CHEMBL186082 | — | — | 1 | 5.28 |
| CHEMBL365709 | — | — | 1 | 5.14 |
| CHEMBL186198 | — | — | 1 | 5.00 |
| CHEMBL362885 | — | — | 1 | 4.85 |
| CHEMBL187064 | — | — | 1 | 4.82 |
| CHEMBL362096 | — | — | 1 | 4.82 |
| CHEMBL186554 | — | — | 1 | 4.77 |
| CHEMBL189251 | — | — | 1 | 4.70 |
| CHEMBL366289 | — | — | 1 | 4.64 |
| CHEMBL188998 | — | — | 1 | 4.62 |
| CHEMBL273665 | — | — | 1 | 4.62 |
| CHEMBL187526 | — | — | 1 | 4.60 |
| CHEMBL185757 | — | — | 1 | 4.60 |
| CHEMBL365920 | — | — | 1 | 4.57 |
| CHEMBL443223 | — | — | 1 | 4.54 |
| CHEMBL415285 | — | — | 1 | 4.52 |
| CHEMBL362326 | — | — | 1 | 4.50 |
| CHEMBL188258 | — | — | 1 | 4.46 |
| CHEMBL189397 | — | — | 1 | 4.44 |
| CHEMBL184070 | — | — | 1 | 4.41 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 4.35 |
| CHEMBL188507 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186731 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL264504 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL362773 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL364175 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL362530 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL186760 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL188890 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL185959 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL186082 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL365709 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL186198 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL362885 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL187064 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL362096 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL186554 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL189251 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL366289 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL188998 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL273665 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL187526 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL185757 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL365920 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL443223 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL415285 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL362326 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL188258 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL189397 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL184070 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL188507 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL186224 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL360003 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL184529 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL359984 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL186964 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL186807 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL189398 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL363064 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL186064 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL189868 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL188535 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL366103 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL186330 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL123143 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL188679 | — | IC50 | > | 100000.0 | nM | - |