Assay Detail
Functional
CHEMBL834064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activity at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 3 (CHEMBL3744) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.50 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370038 | — | — | 1 | 6.96 |
| CHEMBL94859 | — | — | 1 | 6.48 |
| CHEMBL370941 | — | — | 1 | 5.46 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 5.42 |
| CHEMBL372643 | — | — | 1 | 4.50 |
| CHEMBL193087 | — | — | 1 | 4.15 |
| CHEMBL317790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370038 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL94859 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL370941 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL276815 | (S)-AMPA | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL372643 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL193087 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL317790 | — | EC50 | > | 1000000.0 | nM | - |