Assay Detail
Functional
CHEMBL834068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCP-1 induced chemotaxis in THP-1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255408 | — | — | 1 | 7.70 |
| CHEMBL435499 | — | — | 1 | 7.40 |
| CHEMBL2096789 | — | — | 1 | 6.44 |
| CHEMBL181432 | — | — | 1 | 6.21 |
| CHEMBL2448120 | — | — | 1 | 6.20 |
| CHEMBL2096788 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255408 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL435499 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2096789 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL181432 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2448120 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2096788 | — | EC50 | = | 810.0 | nM | 6.09 |