Assay Detail
Functional
CHEMBL834105
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Inhibitory concentration of compound against human renal proximal tubular epithelial cells (RPTEC) was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPTEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.77 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191635 | — | — | 1 | 5.48 |
| CHEMBL365159 | — | — | 1 | 5.39 |
| CHEMBL192145 | — | — | 1 | 5.09 |
| CHEMBL193282 | — | — | 1 | 4.55 |
| CHEMBL192062 | — | — | 1 | 4.54 |
| CHEMBL273986 | — | — | 1 | 4.50 |
| CHEMBL191786 | — | — | 1 | 4.33 |
| CHEMBL192647 | — | — | 1 | 4.26 |
| CHEMBL190518 | — | — | 1 | - |
| CHEMBL352683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191635 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL365159 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL192145 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL193282 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL192062 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL273986 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL191786 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL192647 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL190518 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL352683 | — | IC50 | > | 200000.0 | nM | - |